Kolpack and Izzo were probably going to use this so sorry if it's a spoiler:
Since going starting DI in 2004, NDSU is 28-0 in home non-conference games (which was my contribution to the NDSU fact-of-the-day thread on AGS.)
The average score of those games: 42-11, even though 6 of those games were in the playoffs. Of course, when NDSU started DI, there were a couple D2s and Valpo on the schedule.